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Senior Software Engineer
Xilis
Software Engineering
Durham, NC, USA
Posted on Mar 29, 2025
Xilis, Inc. is an innovation-driven biotech company developing its proprietary MicroOrganoSphere (“MOS”) Technology for functional precision oncology. Xilis’ MOS Technology enables rapid and scalable generation of patient tumor models that retain patient-specific tumor biology and tumor microenvironment, representing one of the most translationally-relevant ex vivo technologies for precision oncology drug discovery and development. Located in Research Triangle Park, Durham, NC, Xilis is building a functional precision medicine platform that incorporates scaled multi-modal profiling of therapeutic activity and AI/ML-enabled analytics to catalyze functional precision medicine drug discovery, development and diagnostics. Collectively, Xilis aims to harness its MOS Platform to enable development of the most effective therapeutics and guide them to the right patients at the right time.
Impact
Your work will directly contribute to advancing cancer care through innovative technology. Our proprietary MOS hardware is a sophisticated microscale encapsulation system for manipulating and studying complex 3D tissue models, combining microfluidics, extracellular matrices, robotics, and specialized protocols. As a Senior Software Engineer, you will play a crucial role in enhancing this revolutionary platform that guides precision therapy for cancer patients and accelerates drug discovery and development.
Main Objectives
- Design, develop, and support the device software for our revolutionary MicroOrganoSphere (MOS) technology
- Enhance device capabilities by implementing sensor integration and data collection systems that maximize device efficiency and performance
- Develop additional applications and features to support MOS creation and functional assays
- Collaborate with cross-functional hardware engineering and data science teams to drive innovation in our tech platform
Responsibilities
- Integrate diverse sensors and hardware components using manufacturer libraries and SDKs
- Develop and design software logic systems for error detection, handling, and response, based on system readouts from hardware components
- Create robust data pipelines to synchronize device data with our AWS data lake
- Build intuitive, responsive on-device user interfaces
- Implement comprehensive logging and monitoring systems for device operations
- Collaborate with data scientists to develop and deploy device-specific algorithms that enhance operational efficiency and output quality
- Troubleshoot and resolve software issues to ensure reliable device operation, including PCBs and onboard computers
- Develop and maintain standard operating procedures (SOPs) for device operation to support laboratory workflows
Requirements
- 7+ years of professional software engineering experience focused on embedded systems, device drivers, and integration with hardware components.
- Strong understanding of hardware-software integration, embedded systems, real-time processing, and how to interface with physical devices (e.g., sensors, actuators, communication buses, PCBs, microcontrollers).
- Proficiency in Python for instrument control, data acquisition, and device communication protocols
- Experience building and integrating APIs on AWS
- Experience with Git version control, CI/CD pipelines, and agile development
- Experience with Linux systems
- Bachelor’s degree in Electrical Engineering, Computer Engineering, or related technical field
Preferred Qualifications
- Background in life sciences or biotechnology
- Knowledge of regulatory requirements for laboratory instrumentation
- Background in electrical engineering or hands-on experience with hardware fundamentals such as signal processing, circuit-level debugging, or hardware bring-up.
- Prior experience with microfluidics or lab automation systems
- Experience with C/C++ for performance-critical applications
- Knowledge of UI/UX design principles for instrumentation interfaces
Xilis was created when its three founders — an engineer, a physician, and a biologist — decided to come together and commercialize their technology to transform cancer care. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. We do not discriminate on the basis of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or Veteran status. Furthermore, even if your work experience isn't perfectly aligned with what we've described above, if you're excited about what we're building then we want to talk to you!
Xilis offers comprehensive health, vision, dental & retirement plans, and unlimited PTO. We are a remote-friendly team: our headquarters are in Durham, North Carolina, but we have team members across the US (and beyond!).