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CREATE Medicines is a clinical-stage biotechnology company focused on developing RNA-based immunotherapies through in vivo immune cell programming. Its platform uses proprietary mRNA-lipid nanoparticle (mRNA-LNP) technology to directly program immune cells such as T cells, NK cells, and myeloid cells within the body, with applications in cancer, autoimmune diseases, and fibrosis. The company is advancing a pipeline of in vivo CAR therapies, including programs for breast cancer, epithelial tumors, and B cell depletion, with several candidates currently in clinical and preclinical development. CREATE Medicines also develops targeted receptor and RNA engineering technologies designed to support repeat dosing and multi-immune cell programming. Its research and clinical efforts are centered on creating scalable immunotherapy approaches that avoid the need for traditional ex vivo cell engineering processes.