Research Associate II/Senior Research Associate - Non-Viral Capabilities

Mammoth Biosciences

Mammoth Biosciences

Brisbane, CA, USA
Posted on Wednesday, May 15, 2024
We are currently seeking a Research Associate II (RA II)/Senior Research Associate (SRA) to join Mammoth’s Non-Viral Capabilities Team. In this role, the successful candidate will support Mammoth’s proprietary CRISPR nuclease systems for a variety of therapeutic indications, supporting the production and characterization of RNA. This opportunity is well-suited for a team-player with technical expertise in downstream purification techniques and hunger for learning and growth.


  • The RA II/SRA will be a member of the Non-Viral Capabilities group, supporting laboratory research to produce and purify mRNA candidates for multiple therapeutic programs with Mammoth’s organization
  • Evaluate and implement purification technology and optimized existing techniques and workflows
  • Assume responsibility for critical reagent sourcing and maintain adequate supply and inventory
  • Plan, execute and carefully document experimental results in a time sensitive manner using Electronic Lab Notebook (ELN) systems and clearly communicate to internal stakeholders
  • Contribute to development and optimization of new technologies and methods related to improve mRNA synthesis and purification


  • BS in Biology, Molecular Biology or related discipline with 2+ years of experience
  • Experience with mRNA synthesis at different scales (High-throughput, medium scale), large-scale/multi-step chromatography (e.g. RP-HPLC, SEC) and tangential flow filtrations, along with a strong understanding of molecular biology and general lab operations
  • Excellent communication, organizational and problem-solving skills
  • Proven ability to work independently and cross-functionally with highly skilled teams in fast-paced environments


  • Background in nucleic acid characterization techniques
  • Experience in CRISPR Therapeutics using non-viral delivery


  • Company-paid health/vision/dental benefits
  • Unlimited vacation and generous sick time
  • Company-sponsored meals and snacks
  • Wellness, caregiver and ergonomics benefits
  • 401(k) with company matching
Base Salary Range: $84,938 - $90,100
The listed base salary range is for Mammoth employees in the Bay Area. Actual base salary will be determined by geographic work location, relevant professional experience, applicable skills, and internal equity. The base salary range for those working remotely outside of the San Francisco Bay Area may differ and will be determined by industry market data for the role and specific region.
Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.
It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.
Mammoth Biosciences requires that all employees be vaccinated against Covid-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.