Senior Research Associate, Therapeutic Genome Editing - Neuromuscular

Mammoth Biosciences

Mammoth Biosciences

Brisbane, CA, USA
Posted on Tuesday, August 8, 2023
Mammoth is currently seeking a talented and detail-oriented Senior Research Associate to join our therapeutic genome editing team. The successful candidate will work closely and collaboratively with colleagues to design/develop, perform and execute translational research studies on mammalian cell lines and primary human cells and in mice to support the development of Cas nucleases for human therapeutics. The position requires adaptability, excellent technical and analytical skills, strong organizational and communication skills, as well as the ability to work independently in a fast-paced team-oriented and dynamic environment.


  • Execution of molecular biology, cloning, cell culture, genome editing, transfection, viral transduction and a broad range of functional assays
  • Provide technical support for phenotyping and analytical characterization of cellular or animal models and genome editing outcomes
  • Accurately and timely record, document, analyze and communicate laboratory data to senior staff and team members
  • Conducts all activities in a safe and efficient manner, and adheres to site environmental health and safety (EHS) requirements


  • Bachelor’s degree in molecular and cell biology, immunology, biochemistry, or a related field
  • 5 years relevant laboratory research experience
  • Knowledge of gene editing systems
  • Proficiency in mammalian cell culture, transfections, viral transductions, molecular cloning, PCR, genomic DNA and mRNA purification, cDNA library prep, qPCR, ddPCR, NGS library prep, ELISA, western blot


  • 2+ years industry work experience
  • Master’s degree
  • Experience working with AAV and/or LNP
  • Experience with NGS sample preparation
  • Experience with complex cell culture systems (cardiomyocytes, myoblasts, myotubes) or patient derived cells (iPSC, fibroblasts)
  • Experience developing human therapies using genome editing systems
  • Knowledge of Microsoft Office Suite and other relevant data analysis software (Flowjo, GraphPad Prism, etc.)
  • Strong organizational and record-keeping skills, excellent interpersonal, verbal and written communication skills. Highly motivated with strong work ethics. Ability to work efficiently and productively in a fast-paced highly collaborative team environment


  • Company-paid health/vision/dental benefits
  • Unlimited vacation and generous sick time
  • Company-sponsored meals and snacks
  • Wellness, caregiver and ergonomics benefits
  • 401(k) with company matching