Senior Scientist/Principal Scientist, Translational Biology

Hexagon Bio

Hexagon Bio

Menlo Park, CA, USA
Posted on Saturday, March 30, 2024

About Hexagon Bio:

Hexagon Bio leverages a genomics-based platform and understanding of natural product evolution to develop next-generation medicines for human disease, including Antibody Drug Conjugates (ADCs) with novel payloads. Our algorithms identify gene clusters that encode the machinery needed to produce specialized metabolites and our unique platform allows us to produce new chemical leads and novel payloads based on these findings. We use data science, genomics, synthetic biology, and automation to discover and develop potent, evolutionarily refined small molecules from fungal genomes, paving the way for groundbreaking advancements in ADC therapeutics.

Location: Menlo Park, CA

Job description:

As Senior Scientist/Principal Scientist, Translational Biology you will be part of a highly collaborative, interdisciplinary team, and will be responsible for the development and characterization of natural-product-derived cytotoxic payloads, contributing to the advancement of ground breaking therapeutic interventions. You will be responsible for designing, executing and implementing experimental strategies to drive our safety science forward, through various in vitro and in vivo approaches. By collaborating with chemists, biochemists, and cell biologists, your work will guide the design and selection of drug candidates with the “right safety” profile. We are seeking innovative team members inspired by our mission to work collaboratively in building the next-generation drug company. Candidates should demonstrate leadership, scientific curiosity, efficient time management, excellent organizational and communication skills, and a passion for science.

The role is expected to be a mix of laboratory work and CRO management.

Key Responsibilities:

  • Design and perform in vitro experiments to evaluate the safety of antibody-drug conjugates (ADCs).
  • Analyze experimental data using appropriate statistical methods, interpret results to guide decision-making processes.
  • Design and monitor non-GLP and GLP toxicology studies to support characterization of development candidates.
  • Collaborate with a diverse team of biologists, chemists and CROs to answer scientific questions and deliver quality and timely findings in support of candidate advancement.
  • Effectively communicate findings and interpretation of results to multi-disciplinary teams.
  • Stay abreast of preclinical safety approaches applied to ADCs.
  • Comply with company health and safety policies and general laboratory practices.


  • PhD in Cancer Biology, Immunology, Toxicology, Pharmacology, or related discipline with 5-8 years of industrial experience.
  • Familiarity with ADCs characterization is a plus.
  • Hands-on experience with in vitro cellular biology and immunology assays in mammalian tumor cells.
  • Knowledge in multicolour flow cytometry, multiplex cytokine measurements, confocal imaging, and 3D cellular systems.
  • Experience with the design and execution of in vivo non-GLP and GLP safety and toxicology studies.
  • Understanding of the biology around novel drug targets and pathways, develop testable hypotheses and propose innovative solutions to drive scientific learning.
  • A collaborative, team-oriented approach, able to take on problems in a goal-focused fashion
  • Effective communication and ability to coordinate tasks across multiple projects as part of a multidisciplinary research team.
  • Initiative and boldness to dive into a fast-paced new startup.

What We Offer:

  • A flexible and dynamic work environment where you pave your own path, Hexagon cultivates employees' unique strengths at all levels and provides mobility across departments.
  • “All Hands Meetings” provide an opportunity to share company and team updates. These meetings are rooted in our value of transparency. They are designed to foster a culture of collaboration, curiosity, and open communication.
  • Competitive compensation and a robust benefits package: a comprehensive suite of medical, dental, and vision insurance plans through TriNet, which offers additional voluntary benefits (pet insurance, accident insurance, home & auto insurance, and more).
  • Equity and a 401(k) plan.
  • Rapid career advancement for driven performers.
  • Access to scientific conferences all over the country throughout the year.
  • A range of amenities, courtesy of the Menlo Park Labs business park, including shuttle, gym, rock-climbing wall, pool, sports courts, cafe, bike lockers, and free EV charging stations.
  • Opportunities to engage with the Hexagon community through team-building events like our monthly Hexagon Happy Hour and holiday parties.

Additional Information:

The salary range is dependent on the level of Scientist that is hired (Senior Scientist or Principal Scientist). The salary range for this full-time position is $120,000 to $180,000 + bonus + equity + benefits. Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across California locations. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training.

Hexagon Bio is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, disability status, membership in an organization, or any other non-merit factors

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.