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Position: Scientist I/II

Deciduous Therapeutics is an early stage, venture backed biotechnology company based in San Francisco, CA. Our mission is to positively impact human Healthspan by developing novel immunotherapies to treat age-related diseases.

We are seeking an ambitious scientist with a deep background in immunology, focusing on T cell biology. The ideal candidate has deep expertise in analyzing immune responses in mouse models of age-related diseases, such as lung fibrosis (bleomycin-induced IPF model) and metabolic disorders (diet-induced obesity).

For background on the underlying science, please review our founding publication in Cell Press Medicine and a short video summarizing the findings.

Qualifications:

This role requires an independent scientist with excellent communication skills, a passion for exploring the immune system, and a commitment to advancing knowledge in the development of immune-based therapies to treat age-related diseases.

• PhD in immunology with 2+ years of relevant experience in industry.
• Expertise in developing and executing in vivo animal models of age-related diseases (e.g., fibrosis, metabolic disorders).
• Highly skilled in mouse handling and administering therapies via different routes, including IV, IP, intratracheal, intranasal, and ex vivo tissue processing for downstream cellular phenotypic and functional analyses.
• Extensive experience in developing and applying different approaches to interrogate the mechanism of action of immune therapies, including multi-dimensional immune cell phenotyping flow cytometry, in vitro and ex vivo assays to assess T-cell cytotoxicity, proliferation, cytokine production, and other immune functions.
• In-depth knowledge of the principles and practices of cellular and molecular immunology.
• Highly proficient in analyzing & interpreting high dimensional flow cytometry data.
• Outstanding written and oral communication skills and the ability to organize and communicate complex data sets clearly and concisely to key stakeholders from diverse backgrounds.
• Experience in leading and organizing a team of junior scientists and research associates.
• Ability to multi-task and collaborate with peers within a fast-paced team environment with a positive outlook and a high degree of self-motivation and organization.
• Ability to work on complex problems where analysis requires an in-depth evaluation of multiple factors.

Responsibilities

• Establish and apply multiple mouse models of age-related diseases (bleomycin-induced fibrosis and HFD-induced T2D) to investigate the efficacy and MOA of novel immunotherapies.
• Design, develop, and execute a wide range of in vitro and ex vivo cellular characterization assays. This includes using multi-color flow cytometry to evaluate mechanisms of iNKT cell activity and its impact on different immune cell populations. A strong competency with multi-color flow panel design and optimization is preferred.
• Drive scientific and technical innovation, working collaboratively and proactively with colleagues.
• Provide exceptional scientific leadership and mentorship to scientists and research associates.
• Summarize, synthesize, and interpret data across experiments and present findings at all levels of the organization.

Compensation

We offer a competitive salary, stock options commensurate with experience, and health benefits. In addition, we provide a monthly activity stipend to support outside personal interests.

Furthermore, we are a company that strongly believes in fostering the intellectual advancement of our team. As such, in addition to providing individualized professional mentorship, we will support you in external educational opportunities (online courses, seminars, conferences) that intersect with areas of interest for the company.

Deciduous is an equal-opportunity employer. We value diversity of personal identity, experience, and thought. We will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran status, or disability status.

To apply, please send your C.V. to careers@deciduoustx.com