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Senior Scientist, External Programs
BigHat Biosciences
San Mateo, CA, USA
Posted on Nov 16, 2024
The Role: BigHat Biosciences is seeking an exceptional individual for a Senior Scientist on the External Programs team to serve as a program team lead and drive antibody design, discovery, optimization and characterization, in support of therapeutic programs with our external partners.
This role reports directly to Emily Delaney, Sr. Scientist II, External Programs.
- Department
- Lab Science
- Employment Type
- Full Time
- Location
- San Mateo, CA
- Workplace type
- Onsite
Key Responsibilities
- Lead cross-functional project teams (including Data Science, AI/ML, Engineering, Protein Sciences, Automation) on the execution of rapid, iterative multi-objective optimization to identify high-value therapeutic antibodies through gold-standard assays.
- Effectively and regularly synthesize and communicate results and research activity to key decision makers and the broader BigHat team, as well as to external partners.
- Collaborate closely with BigHat leadership and other cross-functional team members to ensure a tight linkage between strategy, research, and development components.
- Develop strategies to generate and optimize novel antibodies that meet and exceed design requirements, as set forth in BigHat’s collaborative external partnerships.
- Source, onboard, develop, and validate bespoke assays to assess in vitro cell-based functional activity of therapeutic antibody candidates.
- Deeply understanding target biology to better design antibodies that meet our candidate profile
- Lead a team in-depth data analysis of each design cycle to better leverage experimental and computational approaches to reach our design goals
Skills Knowledge and Expertise
- Ph.D. in molecular or cell biology, immunology, or related fields.
- 3+ years of advanced research experience in an industry setting.
- Experience with antibody engineering and/or discovery.
- Exceptional written, verbal and visual communication skills.
- Experience presenting and communicating strategy and results to internal and external partners.
- Experience leading direct reports and teams.
- Experience in leading cross-functional project teams, including planning timelines, adhering to budgets, presenting interim key results internally and externally, is a plus.
- Strong scientific track record and publication record.
- Strong data analysis and interpretation skills. Experience working with large datasets.
- Expertise in mammalian cell culture, immunoassay, molecular techniques, cell-based assays, protein expression and characterization (e.g., kinetics, SEC).
- Experience with lab automation is a plus.
- If you love asking questions, tinkering, and diving headfirst into diverse, highly technical projects BigHat could be the right home for you.
About BigHat Biosciences
BigHat Biosciences designs safer, more effective biologic therapies for patients using machine learning and synthetic biology.
BigHat integrates a wet lab for high-speed characterization with machine learning technologies to guide the search for better antibodies. We apply these design capabilities to develop new generations of safer and more effective treatments for patients suffering from today’s most challenging diseases.
BigHat integrates a wet lab for high-speed characterization with machine learning technologies to guide the search for better antibodies. We apply these design capabilities to develop new generations of safer and more effective treatments for patients suffering from today’s most challenging diseases.
BigHat is a Series B biotech outside San Francisco with a team-oriented, inclusive, and family-friendly culture. Our broad pipeline of wholly-owned and partnered therapeutic programs span many disparate indications with high unmet need, such as cancer, inflammation, and infectious disease. BigHat has raised >$100M from top investors, including Section 32, a16z, and 8VC.
Our Hiring Process
Stage 1:
Applied
Stage 2:
Initial Conversation | Head of Talent
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