Scientist, Tissue Biology (Chalut Lab)

Altos Labs

Altos Labs

Cambridge, UK
Posted on Wednesday, May 15, 2024

Our Mission

Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life.

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Our Value

Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission.

Diversity at Altos

We believe that diverse perspectives are foundational to scientific innovation and inquiry.

We are building a company where exceptional scientists and industry leaders from around the world work side by side to advance a shared mission.

Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives.

At Altos, we are all accountable for sustaining a diverse and inclusive environment.

What You Will Contribute To Altos

An exciting opportunity is available for Scientists to join the Chalut group at Altos Labs, Cambridge Institute of Science (Cambridge, UK). We are seeking very highly motivated, scientifically visionary, creative, and collaborative individuals who are passionate and dedicated about employing their expertise to unravel the deep biology of tissue health. This includes the elucidation of age-related changes in tissue and organs, particularly in the extracellular matrix of the stromal niche and signalling from the niche, and how that ultimately drives tissue function.

The Chalut Lab

The Chalut Lab has been a pioneer in demonstrating the importance of mechanical signalling from the extracellular matrix (ECM) for cell function, in development, disease and ageing. Recently, we have focused on animal tissues and tissue models, to show the centrality of the ECM in driving loss of tissue function. We work across multiple tissues to understand how the ECM niche, particularly composition and function, is changing with age, and which of those changes drive loss of tissue function. We are using our findings to predict and develop interventions in the ECM. At Altos, we are devoted to bringing a new understanding to the role of the niche in tissue function and how to perform interventions in the ECM to alleviate age-related disease.


  • Develop a research area around age-associated changes of the ECM within a new tissue for the lab, preferably the musculoskeletal system.
  • Work together with others in the lab to advance technology to assay tissue health and changes in the ECM.
  • Work together with others to develop animal models to test interventions in ECM to alleviate loss of tissue function.
  • Collaborate widely across Altos to multiply efforts to gain insight into the centrality of tissue function in ageing.
  • Engage in ground-breaking and innovative science and in Altos scientific activities.
  • Present data to a variety of audiences including senior executives through entry-level employees.
  • Carry out research projects in collaboration with the principal investigator, members of the group and other labs within Altos.

Who You Are

Minimum Qualifications

  • PhD in Life Sciences or equivalent field
  • Molecular and cell biology; prior expertise in tissue biology, ECM biology, and/or aging biology
  • Extensive experience with in vivo work and/or experience in mammalian tissue culture (including primary cells)
  • Knowledge and strong interest in studying age-related molecular changes.
  • A strong sense of collective ownership of projects within the group and Altos.
  • Critical, visionary, and creative thinking with an ability to formulate scientific questions, design strategies, and implement plans effectively.
  • Ability to work independently and with others.
  • A demonstrated high productivity and ability to complete work promptly.
  • Problem-solving skills to identify potential issues, test, and develop innovative solutions.
  • Excellent writing and communication skills

Preferred Qualifications

  • Experience with animal handling and models
  • Experience working with live and fixed tissue

The salary range for Cambridge, UK:

  • Scientist I, Biological Sciences: £47,600 - £70,000
  • Scientist II, Biological Sciences: £56,000 - £85,000

Exact compensation may vary based on skills, experience, and location.

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- This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment.

What We Want You To Know

We are a culture of collaboration and scientific freedom, and we believe in the values of diversity, inclusion and belonging to inspire innovation.

Altos Labs provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Altos currently requires all employees to be fully vaccinated against COVID-19, subject to legally required exemptions (e.g., due to a medical condition or sincerely-held religious belief).

Thank you for your interest in Altos Labs where we strive for a culture of scientific freedom, learning, and belonging.

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